PAROXETINE HYDROCHLORIDE

PAROXETINE HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO.

61869-08-7 (Base)

PAROXETINE HYDROCHLORIDE

EINECS NO.

FORMULA

C₁₉H₂₀FNO₃

MOL WT.

329.37

H.S. CODE

TOXICITY

SYNONYMS

Paxil;

(-)-trans-4R-(4'-fluorophenyl)-3S-((3',4'-methylenedioxyphenoxy)methyl)piperidine hydrochloride;

SMILES

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white powder

MELTING POINT

118 - 125 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

SOLVENT SOLUBILITY

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions.

APPLICATIONS

Paroxetine is a selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI) used in the treatment of depression, obsessive-compulsive disorder, and panic disorder. It is a phenylpiperidine derivative which is not related to the tricyclic or tetracyclic antidepressants chemically. The hydrochloride salt of it is administered orally. Chemically, it is (-)-trans-4R-(4'-fluorophenyl)-3S-[(3',4'-methylenedioxyphenoxy) methyl] piperidine hydrochloride hemihydrate. Paroxetine hydrochloride is a white to off-white powder; melting point of 118 - 125 C; soluble in waer (5.4 mg/ml).

SSRIs are used to treat depressions and effective for obsessive-compulsive disorder, posttraumatic stress disorder, premenstrual dysphoric mood disorder, panic disorder, generalized anxiety disorder, and bulimia. Drugs used to treat depressions include;

TRICYCLIC ANTIDEPRESSANTS

Amitriptyline [CAS #: 50-48-6, 549-18-8 (HCl)]

Amoxapine [CAS #: 14028-44-5]

Clomipramine [CAS #: 303-49-1]

Desipramine [CAS #: 50-47-5 58-28-6 (HCl)]

Doxepin [CAS #: 1668-19-5, 1229-29-4 (HCl)]
Imipramine [CAS #: 50-49-7, 113-52-0 (HCl)]
Nortriptyline [CAS #: 894-71-3 (HCl)]
Protriptyline [CAS #: 438-60-8, 1225-55-4(HCl)]
Trimipramine [CAS #: 739-71-9, 521-78-8 (Maleate)]

TETRACYCLIC ANTIDEPRESSANT
- Maprotiline [CAS #: 10262-69-8, 10347-81-6 (HCl)]

MONOAMINE OXIDASE INHIBITORS
- Isocarboxazid [CAS #: 59-63-2, 24631-64-9 (Sulfate)]
- Phenelzine [CAS #: 51-71-8, 156-51-4 (Sulfate)]
- Tranylcypromine [CAS #: 155-09-9]

SELECTIVE SEROTONIN REUPTAKE INHIBITORS
- Fluoxetine [CAS #: 54910-89-3, 59333-67-4 (HCl)]
- Paroxetine [CAS #: 61869-08-7]
- Sertraline [CAS #: 79617-96-2, 79559-97-0 (HCl)]
- Escitalopram Oxalate [CAS #: 128196-01-0]
- Citalopram [CAS #: 59729-33-8, 59729-33-8 (HBr)]
- Fluvoxamine [CAS #: 54739-18-3, 6387-89-9 (Maleate)]

SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR
- Duloxetine [CAS #: 116539-59-4]

PSYCHOSTIMULANTS

Dextroamphetamine [CAS #: 51-64-9, 51-63-8 (Sulfate)]
Methylphenidate [CAS #: 113-45-1, 298-59-9 (HCl)]

MODIFIED ANTIDEPRESSANTS
- Trazodone [CAS #: 19794-93-5, 25332-39-2 (HCl)]
- Venlafaxine [CAS #: 93413-69-5, 99300-78-4 (HCl)]
- Nefazodone [CAS #: 83366-66-9]
- Mirtazapine [CAS #: 61337-67-5]
- Bupropion [CAS #: 31677-93-7]
- Buspirone [CAS #: 36505-84-7]
- Reboxetine [CAS #: 71620-89-8]

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

99.0 - 101.0%

MELTING POINT

118 - 125 C

OPTICAL ROTATION

-86° ~ -89°

TRANSPORTATION

PACKING

HAZARD CLASS

UN NO.

PRICES